Synthesis of 3-pyrroline via domino Heck–aza-Michael reaction
✍ Scribed by Pan Wu; Hui Liu; Xiaofeng Tong
- Book ID
- 116909678
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- French
- Weight
- 650 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0040-4039
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## Abstract A highly stereoselective synthesis of E-isomer of aldoximes was developed through a base-catalysed domino aza-Michael/retro-Michael reaction of hydroxylamine and 2-(R-benzylidene)malononitrile. This reaction generates (E)-aldoxime diastereomer in high yields (eight examples, isolated yi
## Abstract The domino Mannich/aza‐Michael reaction of γ‐malonate‐substituted α,β‐unsaturated esters with __N__‐protected arylaldimines has been achieved. Catalyzed by bifunctional thioureas, 2,5‐__cis__‐configured polysubstituted pyrrolidines are obtained in good to excellent yields (76–99%), enan