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Organocatalytic Asymmetric Domino Aza-Michael–Mannich Reaction: Synthesis of Tetrahydroimidazopyrimidine Derivatives

✍ Scribed by Li, Hong; Zhao, Junling; Zeng, Lili; Hu, Wenhui


Book ID
121293075
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
849 KB
Volume
76
Category
Article
ISSN
0022-3263

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✍ Dieter Enders; Dominik P. Göddertz; Christian Beceño; Gerhard Raabe 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 230 KB 👁 2 views

## Abstract The domino Mannich/aza‐Michael reaction of γ‐malonate‐substituted α,β‐unsaturated esters with __N__‐protected arylaldimines has been achieved. Catalyzed by bifunctional thioureas, 2,5‐__cis__‐configured polysubstituted pyrrolidines are obtained in good to excellent yields (76–99%), enan