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Synthesis of 3-(hydroxymethyl-14C)-8-methoxychromone-214C and 3-hydroxymethyl–8-methoxychromone-4-14C

✍ Scribed by E. J. Merrill; A. D. Lewis

Publisher
John Wiley and Sons
Year
1977
Tongue
French
Weight
311 KB
Volume
13
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A simple route to 3‐(hydroxymethyl‐^14^C)‐8‐methoxychromone‐2‐^14^ using formaldehyde‐^14^C is described. However, this material was considered to be unacceptable for most biological studies because about 16% of the radioactivity was expired as ^14^CO~2~ in the mouse. The synthesis of 3‐methoxysalicylic (carboxyl‐^14^C) acid is described which was converted in several steps to 3‐hydroxymethyl‐8‐methoxychromone‐4‐^14^C. Only 0.03% of the radioactivity in this compound was expired as ^14^CO~2~.

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