Synthesis of 2′-Azido-2′,3′-didehydro-2′
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Mikhailopulo, Igor A. ;Zaitseva, Galina V. ;Vaaks, Elena V. ;Balzarini, Jan ;De
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Article
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1993
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John Wiley and Sons
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English
⚖ 598 KB
## Abstract Compound 15 – the 2′‐azido analog of the anti‐HIV compound 2′,3′‐didehydro‐2′,3′‐dideoxythymidine – was synthesized. Treatment of 5′‐__O__‐trityl‐β‐D‐ribofuranosylthymine (1) with DAST or MSTF gave the 2,2′‐anhydro derivative 2. The latter and its 3′‐__O__‐benzoate 3 were used for the s