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Synthesis of 3'-azido-2',3'-dideoxyribofuranosylpurines

✍ Scribed by Imazawa, M.; Eckstein, F.


Book ID
120305965
Publisher
American Chemical Society
Year
1978
Tongue
English
Weight
791 KB
Volume
43
Category
Article
ISSN
0022-3263

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Synthesis of 2′-Azido-2′,3′-didehydro-2′
✍ Mikhailopulo, Igor A. ;Zaitseva, Galina V. ;Vaaks, Elena V. ;Balzarini, Jan ;De 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 598 KB

## Abstract Compound 15 – the 2′‐azido analog of the anti‐HIV compound 2′,3′‐didehydro‐2′,3′‐dideoxythymidine – was synthesized. Treatment of 5′‐__O__‐trityl‐β‐D‐ribofuranosylthymine (1) with DAST or MSTF gave the 2,2′‐anhydro derivative 2. The latter and its 3′‐__O__‐benzoate 3 were used for the s