𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 3′-Azido, 2′,3′-Didehydro, and 3′,4′-Didehydro Nucleosides from 5-Alkoxymethyluracils

✍ Scribed by Ahmed E.-S. Abdel-Megied; Erik B. Pedersen; Claus Nielsen


Publisher
Springer Vienna
Year
1998
Tongue
English
Weight
248 KB
Volume
129
Category
Article
ISSN
0026-9247

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


ChemInform Abstract: Synthesis of 3′-Azi
✍ A. E.-S. ABDEL-MEGIED; E. B. PEDERSEN; C. NIELSEN 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

Synthesis of 3'-Azido, 2',3'-Didehydro, and 3',4'-Didehydro Nucleosides from 5-Alkoxymethyluracils. -The synthesis of the title compounds, e.g. (V), (VI), (VII), and (VIII), which do not exhibit any anti HIV and anti Herpes activity, is reported.

Synthesis of 2′-Azido-2′,3′-didehydro-2′
✍ Mikhailopulo, Igor A. ;Zaitseva, Galina V. ;Vaaks, Elena V. ;Balzarini, Jan ;De 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 598 KB

## Abstract Compound 15 – the 2′‐azido analog of the anti‐HIV compound 2′,3′‐didehydro‐2′,3′‐dideoxythymidine – was synthesized. Treatment of 5′‐__O__‐trityl‐β‐D‐ribofuranosylthymine (1) with DAST or MSTF gave the 2,2′‐anhydro derivative 2. The latter and its 3′‐__O__‐benzoate 3 were used for the s

Synthesis and antiviral evaluation of α-
✍ Kohei Yamada; Hiroyuki Hayakawa; Shinji Sakata; Noriyuki Ashida; Yuichi Yoshimur 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 427 KB

We have identified a selective S(N)2' reaction triggered by iodide ion that leads to the ring-opening of 2,2'-anhydro-α-nucleosides. By applying the method, we have synthesized α-D-2',3'-didehydro-2',3'-dideoxy-3'-C-hydroxymethyl nucleosides, designed as potential antiviral agents.

ChemInform Abstract: Synthesis of 2′,3′-
✍ Z. Guo; Y. S. Sanghvi; L. E. Brammer Jr.; T. Hudlicky 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 25 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v