Synthesis of 3-amino derivatives of benzo[b]furo[2,3-c]pyridines
β Scribed by S. V. Tolkunov; M. N. Kal'nitskii; E. A. Zemskaya
- Publisher
- Springer US
- Year
- 1991
- Tongue
- English
- Weight
- 342 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0009-3122
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Chlorination of the __N__βoxides of furo[2,3β__b__]β 1a, β[2,3β__c__]β 1b and β[3,2βc]pyridine 1c with phosphorus oxychloride afforded compounds substituted normally at the Ξ±β or Ξ»βposition to the ring nitrogen, 2a, 2β²a, 2b, 2c, 2β²c and 2β²c, and in addition, in the case of 1b, compounds
## Abstract Bromination of Ξ±βcyanopyridine derivatives of furopyridines 1aβd gave the 2,3βdibromoβ2,3βdihydro compounds 2aβd in excellent yields. Treatment of 2aβd with sodium hydroxide in methanol yielded compounds formed through the dehydrobromination and solvolysis of the nitrile. __N__βOxidatio
In a three-step sequence starting from readily available starting materials, 2,3-carbon disubstituted furo[2,3-b]pyridines can be accessed in good yields and purity. Furo[2,3-b]pyridines bearing ester, amide and ketone groups at the 2-position can be prepared with a variety of aryl and alkyl groups