## Abstract The synthesis of the title compound **2** is described. __N__‐Alkylation of 5′‐amino‐5′‐deoxy‐2′,3′‐__O__‐(1‐methylethylidene)adenosine (**3**) with [(3‐iodopropoxy)methyl]benzene gave after debenzylation the 5′‐deoxyadenosine derivative **4b**. After derivatization of the 5′‐NH, the te
Synthesis of 3′-amino-3′-deoxyadenosine 5′-triphosphate
✍ Scribed by G. M. Visser; Cecile Schattenkerk; J. H. van Boom
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 457 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0165-0513
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📜 SIMILAR VOLUMES
A S-O-silylated-2',3'-anhydroadenosine derivative underwent epoxide opening smoothly with dimethylboron bromide. The N-benzyl carbamate derived from the trans bromohydrin was ring-closed with sodium hydride. Deprotection (fluoride, hydroxide, and hydrogenolysis) gave 3'-amino-3'-deoxyadenosine (6)
Cycloaddition of diazomethane with 3'-deoxy-3'-methylene-and 4',S-didehydro-5'-deoxynucleoside derivative8 followed by sensitized photochemical extrusion of nitrogen provided the previously unreported 3'-and 4'-spirocyclopropane nucleoside derivatives. Enhancement of the cycloaddition reactions by e
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