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Molecular orbital studies on nucleoside antibiotics. IV. conformation of 3'-deoxyadenosine (cordycepin) and 3'-amino-3'-deoxyadenosine

✍ Scribed by Anil Saran; Lalit N. Patnaik

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
479 KB
Volume
20
Category
Article
ISSN
0020-7608

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✦ Synopsis

Abstract

PCILO computations have been carried out on the conformation of 3'‐deoxyadenosine (cordycepin) and 3'‐amino‐3'‐deoxyadenosine. These nucleoside antibiotics results as a consequence of modification in the sugar part of adenosine. Both C(2')‐endo and C(3')‐endo sugar puckerings have been considered in the computations and the results obtained indicate that these nucleoside antibiotics have very similar conformational preferences as compared to those of the parent nucleoside adenosine. This similarity which is quite marked in aqueous solution has important biological significance.

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