A seven-step 'synthesis of 3-amino-l-methyl-9FJ-[4-l 'Clpyrido-[ 3,4-&] indole from DL-[methylene-"C] tryptophan and acetaldehyde is described.
Synthesis of 3-amino-1-methyl-5H-pyrido[4,3-b]indole-1-14C (TRP-P-2)
✍ Scribed by E. J. Reist; W. W. Bradford; G. R. Gordon; J. H. Peters
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- French
- Weight
- 191 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
A practical 2‐step synthesis of 3‐amino‐1‐methyl‐5H‐pyrido[4,3‐b]indole‐1‐^14^C is described, starting from 2‐cyanomethyl indole and carbonyl‐labeled acetyl chloride.
📜 SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract The synthesis of 5‐Fluoro‐3‐[3‐[4‐(2‐[^14^C]‐5‐methoxy‐4‐pyrimi‐dinyl)‐1‐piperazinyl]propyl]‐1H‐indole dihydrochloride (5) was achieved by coupling [^14^C] formamidine acetate (1) and dimethylmethoxymalonate in methanol containing sodium methoxide at 60°C to provide 2‐[^14^C] 4,6‐dihydr