Synthesis of 3-acetyl-2-amino-4-pyridone
✍ Scribed by V. A. Dorokhov; A. V. Komkov; A. M. Sakharo; V. S. Bogdanov
- Book ID
- 112537635
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 347 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1573-9171
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📜 SIMILAR VOLUMES
## Abstract Azidation of the chlor aldehyde 2, which was obtained from the 4‐hydroxy‐2‐pyridone 1, afforded the ring‐closed isoxazolopyridone 3. Thermolysis of the 3‐acetyl‐4‐azido‐2‐pyridone 8, which was obtained from the corresponding 4‐tosyloxy derivative 7, afforded isoxazolopyridine 9. Aminati
The title compound, C~11~H~10~N~2~O, a potential antitumour drug, crystallizes with two molecules in the asymmetric unit. The 4-amino N atom is strongly conjugated with the quinoline ring involving the 3-carbonyl group. As a result, the molecule is almost planar. The amino group is involved in both