Synthesis of 3-(2-benzothiazolylthio)propanenitrile and related products
โ Scribed by John J. D'Amico; Lydia Suba; Peter G. Ruminski
- Book ID
- 112128399
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1986
- Tongue
- English
- Weight
- 385 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0022-152X
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An efficient and facile chemoenzymatic synthesis of duloxetine by lipase mediated resolution of 3-hydroxy-3-(2thienyl)propanenitrile has been achieved. This process also describes an enantioconvergent synthesis of duloxetine via a Mitsunobu reaction.
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