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Synthesis of (2R,5R)-5-Chloropipecolic Acid via a Homochiral Acyliminium Ion Intermediate

✍ Scribed by Herdeis, Claus ;Held, Walter A. ;Kirfel, Armin

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
378 KB
Volume
1994
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

An efficient synthesis of (2__R__,5__R__)‐5‐chloropipecolic acid hydrochloride (11) is described, starting from the readily available methyl (S)‐5‐(tert‐butyldimethylsilyloxy)‐2‐oxopiperidine‐1‐carboxylate (3).

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