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Synthesis of 2H, 13C and 15N-isotopomers of acetonitrile and thioacetamide

✍ Scribed by Uffer Anthoni; Per Halfdan Nielsen

Publisher: John Wiley and Sons
Year: 1984
Tongue: French
Weight: 217 KB
Volume: 21
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580210412

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✦ Synopsis

The syntheses of all the possible 2 H , 1 3 C , and 15N singly and multigly labelled isotopomers of acetonitrile and thioacetamide are described. The pathway includes reaction between methyl iodide and potassium cyanide followed by treatment of the acetonitrile with diphenylphosphinodithioic acid to give thioacetamide, purified by sublimation in an overall yield of 55-60%.

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