Synthesis of 2‐Deoxy‐2‐Fluoro‐2‐ C ‐Methyl‐ D ‐Ribofuranoses
✍ Scribed by Clark, Jeremy L.; Christian Mason, J.; Hobbs, Ann J.; Hollecker, Laurent; Schinazi, Raymond F.
- Book ID
- 123619482
- Publisher
- Taylor and Francis Group
- Year
- 2006
- Tongue
- English
- Weight
- 138 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0732-8303
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📜 SIMILAR VOLUMES
The relative stereochemistry of the fluoro substituent (as __ribo__) and the ring size of the lactone (as five) in the title compound, C~6~H~9~FO~4~, have been established by X-ray crystallographic analysis.
## Abstract A convenient method for the synthesis of ^18^F‐2‐deoxy‐2‐fluoro‐D‐glucose (4) and ^18^F‐2‐deoxy‐2‐fluoro‐D‐mannose (8) by the direct fluorination of 3,4,6‐tri‐0‐acetyl‐D‐glucal with ^18^F‐F~2~ is described. ^14^C‐2‐deoxy‐2‐fluoro‐D‐glucose has been synthesized from ^14^C‐3,4,6‐tri‐0‐ace