Synthesis of (25R)-26-hydroxy-15-ketosterols☆
✍ Scribed by Hong-Seok Kim; Dong-Il Kim
- Book ID
- 117214141
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 95 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0039-128X
No coin nor oath required. For personal study only.
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25R)-3/3,26-Dihydroxy-5c~-cholest-8( 14)-en-15-one (1) was synthesized in four steps from (25R)-3/3,26-diacetoxycholesta-5,7-diene (111) in 30% overall yield, lsomerization of 111 with HCI in chloroform-dichloromethane at -60°C gave (25R)-3/3,26-diacetoxy-5et-cholesta-7,14-diene together with the 5u
Two new fluorinated 25-hydroxyvitamin D3 analogs, 26,26,26-trifluoro-25-hydroxy (2) and 27-nor-26,26,26-trifluoro-25-hydroxyvitamin D3 (i), were prepared from 24-phenylsulfonyl 25,26,27-triorcholest-5-en-3B-yl tetrahydropyranyl ether (A). It is well known that vitamin D3 must be sequentially hydroxy