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Inhibitors of sterol synthesis. An improved chemical synthesis of 26-oxygenated Δ8(14)-15-ketosterols having the 25R configuration

✍ Scribed by Abdul U. Siddiqui; William K. Wilson; George J. Schroepfer Jr.

Book ID
107737341
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
29 KB
Volume
72
Category
Article
ISSN
0009-3084

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26-Oxygenated derivatives of As04)-15-ketosterols have been synthesized from (25R)-3#,26-diacetoxy-5a-cholest-8( )-en-15-one (IX) as part of a program to prepare potential metabolites and analogs of 3/~-hydroxy-5c~-cholest-8( )-en-15-one (I), a potent regulator of cholesterol metabolism. Partial hyd