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Synthesis of 2,4,8-Trisubstituted 1,7-Naphthyridines by the Reaction of 4-(1-Aryl-2-methoxyethenyl)-3-isocyanopyridines with Excess Organolithiums

✍ Scribed by Kazuhiro Kobayashi; Taketoshi Kozuki; Shuhei Fukamachi; Hisatoshi Konishi

Publisher
John Wiley and Sons
Year
2010
Tongue
German
Weight
153 KB
Volume
93
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

A convenient method for the synthesis of 2,4,8‐trisubstituted 1,7‐naphthyridines 6 by the reaction of (E)‐4‐(1‐aryl‐2‐methoxyethenyl)‐3‐isocyanopyridines 4, which could be easily prepared from commercially available 3‐aminopyridine via aroylation of lithium (4‐lithiopyridin‐3‐yl)pivalamide with N‐methoxy‐N‐methylbenzamides, with excess organolithiums has been developed.

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✍ Kazuhiro Kobayashi; Taketoshi Kozuki; Manami Konishi; Teruhiko Suzuki; Miyuki Ta 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 German ⚖ 145 KB 👁 1 views

## Abstract The reaction of aryl(3‐isocyanopyridin‐4‐yl)methanones **1**, easily prepared from commercially available pyridin‐3‐amine, with aryl __Grignard__ reagents gave, after aqueous workup, 2,3‐diaryl‐3__H__‐pyrrolo[2,3‐__c__]pyridin‐3‐ols **2**. These rather unstable alcohols were __O__‐acyla