Synthesis of 2,4-dideoxy-d-erythro-hexopyranose. An intermediate for synthesis of the lactone moiety of inhibitors of hydroxymethylglutaryl-coenzyme A reductase
β Scribed by Pak-Tsun Ho; Sharon Chung
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 292 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0008-6215
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π SIMILAR VOLUMES
Treatment of methyl 3,5-di-O-benzyl-2-deoxy-a,8-r>-erythro-pentofuranoside with a-toluenethiol and cont. hydrochloric acid gave 3,5-di-0-benzyl-2-deoxy-D-erythro-pentose dibenzyl dithioacetal (21). Mesylation of 21 and ring closure gave benzyl 3,S-di-O-benzyl-2-deoxy-l,4-dithio-a,P-L-threo-pentofura
Methyl 5- O-acetyl-3-azido-2,3-dideoxy-4-thio-a,fl-D-erythro-pentofuranoside and 1,5-O-diacetyl-3-azido-2,3-dideoxy-4-thio-a,[J-D-erythro-pentofuranose were prepared in twelve and thirteen steps, respectively, by an efficient route starting from D-xylose. Both compounds were easily converted into an