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Synthesis of 2,4-Diamino-6-[2‘- O -(ω-carboxyalkyl)oxydibenz[ b , f ]azepin-5-yl]methylpteridines as Potent and Selective Inhibitors of Pneumocystis c arinii, Toxoplasma g ondii , and Mycobacterium a vium Dihydrofolate Reductase

✍ Scribed by Rosowsky, Andre; Fu, Hongning; Chan, David C. M.; Queener, Sherry F.

Book ID: 126846498
Publisher: American Chemical Society
Year: 2004
Tongue: English
Weight: 286 KB
Volume: 47
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm030599o

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## Abstract The synthesis of four previously undescribed 2,4‐diaminopyrido[2,3‐__d__]pyrimidines (**3,4**) and 2,4‐diaminoquinazolines (**5,6**) with a bulky tricyclic aromatic group at the 6‐position is described. Condensation of dibenz[__b,f__]azepine with 2,4‐diamino‐6‐bromomethylpyrido[2,3‐__d_