Synthesis of 2′,3′-dideoxynucleosides from 5-alkoxymethyluracils
✍ Scribed by Ahmed E. -S. Abdel-Megied; Erik B. Pedersen; Carsten M. Nielsen
- Publisher
- Springer Vienna
- Year
- 1991
- Tongue
- English
- Weight
- 743 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0026-9247
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## Abstract For Abstract see ChemInform Abstract in Full Text.
Synthesis of 3'-Azido, 2',3'-Didehydro, and 3',4'-Didehydro Nucleosides from 5-Alkoxymethyluracils. -The synthesis of the title compounds, e.g. (V), (VI), (VII), and (VIII), which do not exhibit any anti HIV and anti Herpes activity, is reported.
## Abstract The trimethylsilyated 6‐dimethylaminopurine 1 was coupled with the 2′,3′‐dideoxyribose derivatives 2a, b and 7 by using trimethylsilyl triflate as catalyst to yield the corresponding nucleosides 3a, b, 4a, b and 8, which were appropriately deprotected to give the desired nucleosides 5a,