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Synthesis of 2′,3′-Dideoxy-2′-fluoro-3′-(hydroxyimino)-, -3′-(methoxyimino)- and -3′-(hydroxyamino)pyrimidine Nucleosides

✍ Scribed by Ahmed Khalil; Christophe Mathé; Christian Périgaud


Book ID
112082798
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
589 KB
Volume
2012
Category
Article
ISSN
1434-193X

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## Abstract A series of novel 3′‐(alkyl(hydroxy)amino)‐2′‐fluoronucleoside analogs were prepared __via__ conjugate addition of __N__‐methylhydroxylamine to various 2‐fluorobutenolides. The adducts **13a** and **16** were obtained as single isomers under absolute control of stereochemistry. The cruc