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Synthesis of 2-β-D-ara- and 2-β-D-xylofuranosylthiazole-4-carboxamide

✍ Scribed by David T. Mao; Victor E. Marquez

Book ID
104233544
Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
231 KB
Volume
25
Category
Article
ISSN
0040-4039

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✦ Synopsis

The syntheses of the heretofore unknown 2-B-D-ara and P-B-D-xylofuranosyl isomers of the antitumor agent tiazofurin have been accomplished. In both cases the stereospecific inversion of the required 2' or 3'-hydroxyl group in the protected parent compound afforded the desired products.

In 1982 it was reported that 2-B-D-ribofuranosylthiazole-4-carboxamide

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