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Synthesis of 2-thioxo-6-trifluoromethyl-1,2-dihydropyridine-3-carbonitrile and ethyl 5-cyano-6-thioxo-1,6-dihydropyridine-2-carboxylate by the SNVin reaction

โœ Scribed by V. D. Dyachenko; R. P. Tkachev; A. D. Dyachenko


Book ID
111459950
Publisher
Springer
Year
2009
Tongue
English
Weight
151 KB
Volume
79
Category
Article
ISSN
1070-3632

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โœ C. A. BATTY; M. K. MANTHEY; J. KIRK; M. MANTHEY; R. I. CHRISTOPHERSON; T. HAMBLE ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 35 KB ๐Ÿ‘ 2 views

Synthesis and Exchange Reactions of 5-Alkyl-2-oxo-6-thioxo-1,2,3,6-Tetrahydropyrimidine-4-carboxylic Acids. -The title compounds are prepared as potential dihydroorotase inhibitors. H/D-exchange studies establish a high tendency towards epimerization at C-5. No epimerization is observed under physi