Synthesis of 2-substituted indoles
β Scribed by S. I. Zav'yalov; A. G. Zavozin; O. V. Dorofeeva; E. E. Rumyantseva
- Book ID
- 112450236
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 240 KB
- Volume
- 40
- Category
- Article
- ISSN
- 1573-9171
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## Abstract For Abstract see ChemInform Abstract in Full Text.
The development of the solid-phase version of the modified Madelung indole synthesis is reported. The chemistry was initiated with the reductive amination of Bal resin using an ortho substituted aniline. The resin bound aniline was acylated with a variety of acid chlorides followed by cyclization wi
Condensation of carboxylic acid esters with organodilithium reagents derived from N-trimethylsilyl-o-toluidine or N-trimethylsilyl-o-ethyl aniline affords substituted indoles. The indole ring system, one of the most prevalent structural subunits in natural products chemistry, has captured the intere