SYNTHESIS OF 2-HALO-4,5-DIFLUOROBENZOIC ACIDS
β Scribed by Braish, Tamim F.; Fox, Darrell E.
- Book ID
- 121857782
- Publisher
- Taylor and Francis Group
- Year
- 1991
- Tongue
- English
- Weight
- 249 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0030-4948
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π SIMILAR VOLUMES
2-Chloro-4,5-difluorobenxoic acid (CDFBA) and related impurities are determined using liquid chromatography (LC). Separations are achieved using a reversed-phase isocratic system with an ion-pair reagent (tetrabutylammonium hydroxide). Unique isomeric impurities observed in commercially produced CDP
## Abstract The 3βchloro and 3βbromoβ2βphenylquinolineβ4βcarboxylic acids were obtained in good yields through a novel procedure, entailing the synthesis of the 3βamino intermediate and the subsequent replacement of the amino group with chlorine or bromine, according to the Sandmeyer reaction.