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Synthesis of 2-(dimethylallyl)-N-hydroxytryptophans from indole

✍ Scribed by Ralf Plate; Harry C.J Ottenheijm

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
234 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

A mild and general method for the synthesis of dimethylallyl tryptophan derivatives 11 and 12 is described. Reaction of the 3-(r,X-dimethyl-allyl) indoles i'a or 7b with the nitroso olefin 8 yields the cycloadducts 9a (93%) and 9b (87%), respectively. Subsequent treatment of 9a with trifluoroacetic

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