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Synthesis of 2′-Deoxyribofuranosides of 8-Aza-7-deazaguanine and Related Pyrazolo[3,4-d]pyrimidines

✍ Scribed by Frank Seela; Herbert Steker

Publisher
John Wiley and Sons
Year
1986
Tongue
German
Weight
845 KB
Volume
69
Category
Article
ISSN
0018-019X

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📜 SIMILAR VOLUMES

8-Aza-2′-deoxyguanosine and Related 1,2,
8-Aza-2′-deoxyguanosine and Related 1,2,3-Triazolo[4,5-d]pyrimidine 2′-Deoxyribofuranosides
✍ Frank Seela; Sigrid Lampe 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 German ⚖ 562 KB

## Abstract The synthesis of 8‐azaguanine __N__^9^‐, __N__^8^‐, and __N__^7^‐(2′‐deoxyribonucleosides) 1–3, related to 2′‐deoxyguanosine (4), is described. Glycosylation of the anion of 5‐amino‐7‐methoxy‐3__H__‐1,2,3‐triazolo[4,5‐__d__]pyrimidine (5) with 2‐deoxy‐3,5‐di‐__O__‐(4‐toluoyl)‐α‐D‐__eryt

Facile Synthesis of 2′-Deoxyribofuranosi
Facile Synthesis of 2′-Deoxyribofuranosides of Allopurinol and 4-Amino-1H-pyrazolo[3,4-d]pyrimidine via Phase-Transfer Glycosylation
✍ Frank Seela; Herbert Steker 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 German ⚖ 468 KB

## Abstract Phase‐transfer glycosylation of 4‐methoxy‐1__H__‐pyrazolo[3,4‐__d__]pyrimidine with the 2‐deoxyribofuranosyl chloride **9** formed the N(1)‐β‐nucleoside **10a** as main product (39%). As by‐products the α‐D‐anomer **11a** (7%) and the N(2)‐isomer **12a** (18%) were isolated. Assignment

A convenient synthesis of pyrazolo[3,4-d
A convenient synthesis of pyrazolo[3,4-d]pyrimidine-4,6-dione and pyrazolo[4,3-d]pyrimidine-5,7-dione derivatives
✍ M. El Haddad; M. Soukri; S. Lazar; A. Bennamara; G. Guillaumet; M. Akssira 📂 Article 📅 2000 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 470 KB

## Abstract Pyrazolo‐[3,4‐__d__]pyrimidine‐4,6‐diones **5** and pyrazolo[4,3‐__d__]pyrimidine‐5,7‐diones **7** were synthesized by Curtius rearrangement of pyrazolic mono‐esters **2** and **3** followed by hetero‐cyclization __via__ the ureas derivatives **4** and **6** under alkaline conditions.

Oligonucleotides Containing Pyrazolo[3,4
Oligonucleotides Containing Pyrazolo[3,4-d]pyrimidines: The Influence of 7-Substituted 8-Aza-7-deaza-2′-deoxyguanosines on the Duplex Structure and Stability
✍ Frank Seela; Georg Becher 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 German ⚖ 186 KB 👁 1 views

Oligonucleotides containing 7-substituted 8-aza-7-deazaguanines ( 6-amino-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones) were prepared by automated solid-phase synthesis. A series of 7-alkynylated 8aza-7-deaza-2'-deoxyguanosines (see 4a ± d) were synthesized with the 7-iodonucleoside 3c as starting