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Synthesis of 2-Deoxy-2,3-didehydro Sialic Acid Analogues and Their Behavior Toward Sialidase from Influenza Virus

✍ Scribed by Kiyoshi Ikeda


Publisher
John Wiley and Sons
Year
2005
Weight
8 KB
Volume
36
Category
Article
ISSN
0931-7597

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## Abstract The peracetylated methyl ester 1 of N‐acetylneuraminic acid was transformed into the oxazoline derivative 2, which was hydrogenated with Pd/C/H~2~ to give the 4‐deoxy‐Neu5Ac2en derivative 3. Acid cleavage of the oxazoline 2 by trifluoroacetic acid (THF) gave the 4‐epi‐Neu5Ac2en derivati

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