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Synthesis of 2-aroylpiperazinyl-4-alkoxyquinazolines by phase-transfer-catalysed heteroaromatic nucleophilic substitution

✍ Scribed by M. C. GÓmez-Gil; V. GÓmez-Parra; F. SÁnchez; T. Torres


Book ID
112127570
Publisher
Journal of Heterocyclic Chemistry
Year
1984
Tongue
English
Weight
236 KB
Volume
21
Category
Article
ISSN
0022-152X

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Heteroaromatic Nucleophilic Substitution
✍ Gómez-Gil, M. Carmen ;Gómez-Parra, Vicente ;Sánchez, Félix ;Torres, TomáS 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 528 KB

## Abstract The synthesis of several 4‐ and 5‐alkoxy‐substituted pyridazin‐3(2__H__)‐ones with hypotensive and β‐blocking activities by phase‐transfer catalysis (PTC) starting from halopyridazin‐3(2__H__)‐ones is described. The nucleophilic displacement reaction proceeds easily at the 5‐position an