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Synthesis of 2-aminoquinazolines from ortho-fluorobenzaldehydes

✍ Scribed by John B. Hynes; Johnny P. Campbell

Book ID
102345973
Publisher
Journal of Heterocyclic Chemistry
Year
1997
Tongue
English
Weight
253 KB
Volume
34
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

The reaction of guanidine carbonate with various ortho‐fluorobenzaldehydes in N,N‐diinethylacetamide was investigated as a potential route for preparing 2‐aminoquinazolines. Eleven new 2‐aminoquinazolines were elaborated in this manner in low to moderate yields. In general the best results were obtained with ortho‐fluorobenzaldehydes possessing an electron withdrawing substituent at the other ortho position. Complex mixtures were obtained using 2‐fluorobenzaldehyde, 2,5‐difluorobenzaldehyde and 2‐fluoro‐5‐methoxybenzaldehyde which were not resolved.

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