Solid Phase Synthesis of 2-Aminoquinazoline-Based Compounds ‡
✍ Scribed by Srivastava, Gaurav K.; Kesarwani, Amit P.; Grover, Rajesh K.; Roy, Raja; Srinivasan, T.; Kundu, Bijoy
- Book ID
- 126956071
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 112 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1520-4766
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2-Aminobenzenethiol, bound through its thiol function to the 2-chlorotrityl (Clt)-, trityl (Trt)-, 4-methyltrityl (Mtt)and 4-methoxytrityl (Mmt)-resins, was acylated at the amino-function by aliphatic and aromatic acids. The obtained 2-N-acylaminobenzenethiols were cleaved from the resin by treatmen
## Abstract The reaction of guanidine carbonate with various __ortho__‐fluorobenzaldehydes in __N,N__‐diinethylacetamide was investigated as a potential route for preparing 2‐aminoquinazolines. Eleven new 2‐aminoquinazolines were elaborated in this manner in low to moderate yields. In general the b