Synthesis of 2-amino-7-(2'-deoxy-.beta.-D-erythro-pentofuranosyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, a new isostere of 2'-deoxyguanosine
โ Scribed by Winkeler, Heinz Dieter; Seela, Frank
- Book ID
- 125995239
- Publisher
- American Chemical Society
- Year
- 1983
- Tongue
- English
- Weight
- 1019 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
1,3-Dihydro-2H-indol-2-ones (oxindoles) and 1,3-dihydro-2H-pyrrolopyridin-2-ones (azaoxindoles) are useful scaffolds that have been explored for various pharmaceutical uses. Herein we report the synthesis of 2-chloro-5,7-dihydro-6H-pyrrolo [2,3d]pyrimidin-6-one (5) and its derivatives, and the appli
## Abstract magnified image A relatively short and efficient method for the utilization of 4,6โdichloroโ2โmethylthioโ5โnitropyrimidine (**1**) in the synthesis of the poly substituted pyrrolo[3,2โ__d__]pyrimidinโ7โone 5โoxides (**6a**โg) is reported. Some new 4โsubstituted 6โchloroโ2โmethylthioโ5โ