Synthesis of 2-amino-3-(ω-aminoalkyl)indoles
✍ Scribed by A. N. Kost; V. G. Zabrodnyaya; Yu. N. Portnov; V. G. Voronin
- Book ID
- 112369476
- Publisher
- Springer US
- Year
- 1980
- Tongue
- English
- Weight
- 410 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0009-3122
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## Abstract In the reaction of ethyl isothiocyanatoacetate with diamines, followed by cyclization of the intermediate product, 3‐monosubstituted thiohydantoins have been obtained. It was found that the reaction course depends on the purity of the isothiocyanate used and also, in the case of dialkyl
a b s t r a c t Bromodimethylsulfonium bromide (BDMS)-catalyzed three-component coupling reaction between indoles, aldehydes, and N-alkylanilines is reported to access substituted 3-aminoalkylated indoles at room temperature in high yields (82-96%) within 1.5-3.5 h. The salient features of this prot