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Bromodimethylsulfonium bromide (BDMS)-catalyzed multicomponent synthesis of 3-aminoalkylated indoles

✍ Scribed by Deepak K. Yadav; Rajesh Patel; Vishnu P. Srivastava; Geeta Watal; Lal Dhar S. Yadav

Book ID: 104098239
Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 294 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.08.065

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✦ Synopsis

a b s t r a c t Bromodimethylsulfonium bromide (BDMS)-catalyzed three-component coupling reaction between indoles, aldehydes, and N-alkylanilines is reported to access substituted 3-aminoalkylated indoles at room temperature in high yields (82-96%) within 1.5-3.5 h. The salient features of this protocol are the simplicity of the procedure, the ready accessibility of the catalyst, its cost effectiveness, and higher yields in relatively short reaction times.

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