We have studied aspirin as a potential chemopreventive for colorectal cancer, completing Phase I studies on aspirin pharmacology and potential biomarker assays (prostaglandins, PGE 2 and PGF 2โฃ and cyclooxygenase modulation) in normal human subjects. These studies have determined the optimal dose of
โฆ LIBER โฆ
Synthesis of 2-(allylthio)pyrazines as a novel cancer chemopreventive agent
โ Scribed by Jong Wook Lee; Bongyong Lee; Nak Doo Kim
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 370 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0253-6269
No coin nor oath required. For personal study only.
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Experimental studies have demonstrated that carcinogenesis is a multistep process in which inappropriate proliferation of cells is a critical determinant. Polyamines support sustained growth and are highly regulated in all cells. The rate limiting enzyme for this pathway is ornithine decarboxylase (