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Synthesis of 2-(alkylamino)benzimidazoles

โœ Scribed by James J. Perkins; Amy E. Zartman; Robert S. Meissner


Book ID
104260555
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
205 KB
Volume
40
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


A general and highly convenient procedure for the synthesis of 2-(alkylamino)benzimidazoles has been developed and a variety of analogs have been efficiently prepared. Included is a dipeptide mimetic in which the guanidine group of an arginine residue has been replaced with a 2-aminobenzimidazole.


๐Ÿ“œ SIMILAR VOLUMES


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Synthesis of 2-(Alkylamino)benzimidazoles. -Reaction of an alkylamine and a 1,2-phenylenediamine with thiocarbonyldiimidazole (I) forms the corresponding mixed thioureas, e.g. (IV). These undergo cyclodesulfurization to produce the title compounds. -(PERKINS,

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