Synthesis of 2-(Alkylamino)benzimidazoles. -Reaction of an alkylamine and a 1,2-phenylenediamine with thiocarbonyldiimidazole (I) forms the corresponding mixed thioureas, e.g. (IV). These undergo cyclodesulfurization to produce the title compounds. -(PERKINS,
โฆ LIBER โฆ
Synthesis of 2-(alkylamino)benzimidazoles
โ Scribed by James J. Perkins; Amy E. Zartman; Robert S. Meissner
- Book ID
- 104260555
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 205 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
A general and highly convenient procedure for the synthesis of 2-(alkylamino)benzimidazoles has been developed and a variety of analogs have been efficiently prepared. Included is a dipeptide mimetic in which the guanidine group of an arginine residue has been replaced with a 2-aminobenzimidazole.
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