✦ LIBER ✦

Synthesis of 2-alkyl-3-vinyloxaziridines as potential antitumor agents

✍ Scribed by Said, Samy B. ;Młochowski, Jacek ;Skarżewski, Jacek

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 337 KB
Volume: 1990
Category: Article
ISSN: 0947-3440
DOI: 10.1002/jlac.199019900187

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A convenient method for the synthesis of previously unknown oxaziridines having unsaturated substituents at the 3‐position (3a–k) is based on the selective oxidation of the imino group of α,β‐unsaturated aldimines 2 with m‐chloroperbenzoic acid. The title compounds and 2‐tert‐butyl‐3‐(phenylethynyl)oxaziridine (3k) exhibit potent activity against experimental tumor cells in vitro.

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