## Abstract A series of novel 3′‐(alkyl(hydroxy)amino)‐2′‐fluoronucleoside analogs were prepared __via__ conjugate addition of __N__‐methylhydroxylamine to various 2‐fluorobutenolides. The adducts **13a** and **16** were obtained as single isomers under absolute control of stereochemistry. The cruc
Synthesis of 2′-3′-Dideoxy-2′-fluoro-3′-thioarabinothymidine and Its 3′-Phosphoramidite Derivative
✍ Scribed by Mohamed I. Elzagheid; Anna Lisa Tedeschi; Masad J. Damha
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 58 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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Abstract
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5 0 -O-Benzoyl-2,3 0 -anhydrothymidine. 60% Methanol in water, retention time 13.1 min. \* 2 0 ,3 0 -Dideoxy-2 0 ,3 0 -didehydrothymidine. Solvents: A -water; B -methanol. Program: 0-40% B/A in 40 min, retention time 33.9 min. TLC was carried out on Silufol plates (Czech Republic). \* 5 0 -O-Benzo