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Synthesis of 2-(2,4-difluorophenyl)-4,5-BI-(4-methoxyphenyl) [2-14C] imidazole

✍ Scribed by P. W. Scott; D. R. Hawkins

Publisher: John Wiley and Sons
Year: 1983
Tongue: French
Weight: 230 KB
Volume: 20
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580200503

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✦ Synopsis

Abstract

The synthesis of 2‐(2,4‐difluorophenyl)‐4,5‐bis(4‐methoxyphenyl)imidazole labelled with carbon‐14 in the 2‐position of the imidazole ring has been achieved in four stages starting from barium [^14^C] carbonate via 2,4‐difluoro‐[carboxyl]^14^C benzoic acid and the corresponding aldehyde. The overall radiochemical yield was 20% and the product obtained with a radiochemical purity in excess of 99% by the analytical systems used.

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