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Synthesis of 2-[2,4-diaminothiazol-5-oyl]benzothiazoles

✍ Scribed by T. F. Abbs Fen Reji; Kallikat N. Rajasekharan

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
117 KB
Volume
47
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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The synthesis of 2‐(4‐amino‐2‐alkylaminothiazol‐5‐oyl)benzothiazoles and 2‐[2,4‐bis(arylamino)thiazol‐5‐oyl]benzothiazoles as benzothiazoloylthiazole analogs of the cytotoxic marine alkaloid dendrodoine is reported. The highly decorated thiazole ring assembly was achieved using 2‐bromoacetybenzothiazole to supply the C5 ring carbon and amidinothioureas of the type R^1^NHCSNHC(NHR^2^)(NHR^3^) to provide the four ring atoms [C4N3C2S1] in a [4+1] thiazole ring construction strategy. The antibacterial activity of these new analogs is reported. J. Heterocyclic Chem., (2010).

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