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ChemInform Abstract: Synthesis of 2-[2,4-Diaminothiazol-5-oyl]benzothiazoles.

✍ Scribed by T. F. Abbs Fen Reji; Kallikat N. Rajasekharan


Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
41
Category
Article
ISSN
0931-7597

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## Abstract magnified image The synthesis of 2‐(4‐amino‐2‐alkylaminothiazol‐5‐oyl)benzothiazoles and 2‐[2,4‐bis(arylamino)thiazol‐5‐oyl]benzothiazoles as benzothiazoloylthiazole analogs of the cytotoxic marine alkaloid dendrodoine is reported. The highly decorated thiazole ring assembly was achieve

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Synthesis and Cyclization of 1-(N-Nitroamidino)thioureas to 2,4-Diaminothiazoles. -Reaction of nitroguanidine (I) with isothiocyanates in the presence of powdered KOH provides 1-(N-nitroamidino)thioureas (III) which react with phenacyl bromides to give unexpectedly 2,4-diaminothiazoles (V) in high