Synthesis of (1R)-(+)-nopinone- and (1S)-(−)-verbenone-derived chiral annulated indenes via electrocyclic reactions
✍ Scribed by Chao Liu; John R. Sowa Jr.
- Book ID
- 103405632
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 207 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
A three-step procedure for the synthesis of chiral annulated indenes is described in which nopinone, verbenone and menthone are converted to their enolate form, alkylated with 2-bromomethylbromobenzene, ring-closed with CrCl 2 /cat. NiCl 2 and dehydrated with catalytic acid.
The palladium(0)-catalyzed reaction of derivatives of g-amino-a,b-unsaturated esters bearing an N-(2-iodobenzoyl) substituent results in an intramolecular Heck reaction, the outcome of which depends on the structure of the substrate as well as on the experimental conditions. The methodology develope
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