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Synthesis of 1,n-Dicarbonyl Derivates Using Carbanions from 1,3-Dithianes

✍ Scribed by Prof. Dr. E. J. Corey; Dr. D. Seebach


Publisher
John Wiley and Sons
Year
1965
Tongue
English
Weight
258 KB
Volume
4
Category
Article
ISSN
0044-8249

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The remarkably simple synthesis of Ξ³-alkylidenebutenolides 3 is achieved by cyclization of the dilithiated 1,3-dicarbonyl compounds 1 with N,N'-dimethoxy-N,N'-dimethylethanediamide (2). This regio- and stereoselective cyclization provides a route to a wide range of butenolides, which are of pharmaco