✦ LIBER ✦
Regio- and Stereoselective Synthesis of γ-Alkylidenebutenolides by Cyclization of Dilithiated 1,3-Dicarbonyl Compounds with N,N′-Dimethoxy-N,N′-dimethylethane- diamide
✍ Scribed by Peter Langer; Martin Stoll
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 90 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0044-8249
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✦ Synopsis
The remarkably simple synthesis of γ-alkylidenebutenolides 3 is achieved by cyclization of the dilithiated 1,3-dicarbonyl compounds 1 with N,N'-dimethoxy-N,N'-dimethylethanediamide (2). This regio- and stereoselective cyclization provides a route to a wide range of butenolides, which are of pharmacological relevance and of importance for natural product synthesis.