Synthesis of 1H-pyrazino[1,2-a]pyrido[2,3-e]pyrazine and 2H-Pyrano[2,3-b]pyrido[2,3-e]pyrazine Derivatives
β Scribed by Francesco Savelli; Alessandro Boido; Gianluca Damonte
- Book ID
- 112131679
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1996
- Tongue
- English
- Weight
- 427 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0022-152X
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## Abstract The synthesis of the title compounds was achieved using the key intermediate ethyl 4,6βdimethylβ3β(pyrrolβ1βyl)thieno[2,3β__b__]pyridineβ2β carboxylate 2. This latter compound was obtained __via__ the interaction of the thienopyridine amino ester 1 with 2,5 dimethoxytetrahydrofuran in a
1H and 13C NMR spectral data for several pyridoΓ2,3-b Γpyrazines and pyridoΓ2,3-b Γpyrazine-N -oxides are reported. The chemical shift assignments were based on 1D-NOE, gradient HSQC and gradient HMQC experiments for some model compounds. 1997 < by John Wiley & Sons, Ltd.