Synthesis of 19-hydroxysteroids. III. An investigation of approaches to the synthesis of 19-hydroxycortisol from cortisol and cortisone
✍ Scribed by N. V. Kovzanko; Zh. N. Kashkan; Yu. G. Chernov
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 781 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0009-3130
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
^)-3-Iso-19,20-dehydro-b-yohimbine has been converted into epiallo-yohimbines and, via a novel regioand stereoselective hydration, into the 18R-hydroxy derivative, an analogue of deserpidine. Its 11-methoxy derivative, also prepared from secologanin, is a potential precursor for a reserpine analogue
## Abstract (±)‐__anti__‐2,4‐Dimethylpentanedioic anhydride (__rac__‐1) was converted in good yields and with high enantiomeric excess by an enzyme‐catalyzed sequential esterification into the (2__R__,4__R__)‐monoester 2 and the (2__S__,4__S__)‐diester __ent__‐3. Best results were obtained with Nov