✦ LIBER ✦
Enzymes in organic synthesis, 19. The enzyme-catalyzed sequential esterification of (±)-anti-2,4-dimethylglutaric anhydride. – An efficient route to enantiomerically enriched mono- and diesters ofanti-2,4-dimethylglutaric acid
✍ Scribed by Ozegowski, Rüdiger ;Kunath, Annamarie ;Schick, Hans
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 319 KB
- Volume
- 1994
- Category
- Article
- ISSN
- 0947-3440
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✦ Synopsis
Abstract
(±)‐anti‐2,4‐Dimethylpentanedioic anhydride (rac‐1) was converted in good yields and with high enantiomeric excess by an enzyme‐catalyzed sequential esterification into the (2__R__,4__R__)‐monoester 2 and the (2__S__,4__S__)‐diester ent‐3. Best results were obtained with Novozym 435, a lipase from Candida antarctica. magnified image