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Synthesis of 19-hydroxysteroids I. New synthesis of 19-hydroxytestosterone

✍ Scribed by N. V. Kovganko; Zh. N. Kashkan; Yu. G. Chernov


Publisher
Springer
Year
1992
Tongue
English
Weight
436 KB
Volume
28
Category
Article
ISSN
0009-3130

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## Abstract The first total synthesis of the natural product (βˆ’)‐(19__R__)‐ibogamin‐19‐ol ((βˆ’)‐**1**) is reported (biogenetic atom numbering). Starting with L‐glutamic acid from the chiral pool and (2__S__)‐but‐3‐en‐2‐ol, the crucial aliphatic isoquinuclidine (= 2‐azabicyclo[2.2.2]octane) core cont