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Synthesis of 17-Acetoxy-6-chloro-21-fluoropregna-4,6-diene-3,20-dione, a Highly Active Oral Progestin

✍ Scribed by Church, Robert F. R.; Weiss, Martin J.


Book ID
127209857
Publisher
American Chemical Society
Year
1965
Tongue
English
Weight
281 KB
Volume
8
Category
Article
ISSN
0022-2623

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Chlormadinone-4-14C acetate ( V ) was synthesized from 17%hydroxyprogesterone-4-14C ( I ) by dehydrogenation to the 4,6-diene ( I I ) which was converted to the 6-chloro-4,6-diene ( I V ) via the intermediate 6a,7aor-epoxy compound ( I I I ) , Acetylation of ( I V ) gave chIormadinone-4-14C acetate