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Oral progestational activity of 6-chloro-17α-hydroxy-16-methyinepregna-4, 6-diene-3,20-dione acetate

✍ Scribed by Z. Čekan; M. Šeda; J. Mikuulášková; K. Syhora


Book ID
118977333
Publisher
Elsevier Science
Year
1966
Tongue
English
Weight
192 KB
Volume
8
Category
Article
ISSN
0039-128X

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The synthesis of 6-chloro-17-hydroxypreg
✍ K. H. Palmer; R. W. Handy; M. E. Wall 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 French ⚖ 329 KB

Chlormadinone-4-14C acetate ( V ) was synthesized from 17%hydroxyprogesterone-4-14C ( I ) by dehydrogenation to the 4,6-diene ( I I ) which was converted to the 6-chloro-4,6-diene ( I V ) via the intermediate 6a,7aor-epoxy compound ( I I I ) , Acetylation of ( I V ) gave chIormadinone-4-14C acetate